26 research outputs found

    Rediscovery and status of Cylindera (s. str.) lunalonga (Schaupp, 1884) (Coleoptera: Carabidae: Cicindelinae) in the San Joaquin Valley of California with a comparison to a Sierra Nevada population

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    Surveys for adult Cylindera (s. str.) lunalonga (Schaupp) (Coleoptera: Carabidae: Cicindelinae) were conducted between 2001 and 2011 at over 80 sites throughout the species’ historic range in the San Joaquin Valley and Sierra Nevada Mountains of California. Previously considered extirpated from the Valley, these surveys resulted in finding adults at 18 sites, several with large populations (>50 individuals). As suggested by historic records, our studies confirmed that the Valley populations of Cy. lunalonga occur in what were historically wetland sites, but are now lowland agricultural croplands. Adults were always associated with wet, muddy soil within and along the edges of irrigation ditches. A comparison of morphology, behavior, habitat, and conservation is made with the only known extant Sierra Nevada population

    Interactive computation of radiation view factors

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    The development of a pair of computer programs to calculate the radiation exchange view factors is described. The surface generation program is based upon current graphics capabilities and includes special provisions which are unique to the radiation problem. The calculational program uses a combination of contour and double area integration to permit consideration of radiation with obstruction surfaces. Examples of the surface generation and the calculation are given

    Director configuration of planar solitons in nematic liquid crystals

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    The director configuration of disclination lines in nematic liquid crystals in the presence of an external magnetic field is evaluated. Our method is a combination of a polynomial expansion for the director and of further analytical approximations which are tested against a numerical shooting method. The results are particularly simple when the elastic constants are equal, but we discuss the general case of elastic anisotropy. The director field is continuous everywhere apart from a straight line segment whose length depends on the value of the magnetic field. This indicates the possibility of an elongated defect core for disclination lines in nematics due to an external magnetic field.Comment: 12 pages, Revtex, 8 postscript figure

    Detection of Epileptogenic Cortical Malformations with Surface-Based MRI Morphometry

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    Magnetic resonance imaging has revolutionized the detection of structural abnormalities in patients with epilepsy. However, many focal abnormalities remain undetected in routine visual inspection. Here we use an automated, surface-based method for quantifying morphometric features related to epileptogenic cortical malformations to detect abnormal cortical thickness and blurred gray-white matter boundaries. Using MRI morphometry at 3T with surface-based spherical averaging techniques that precisely align anatomical structures between individual brains, we compared single patients with known lesions to a large normal control group to detect clusters of abnormal cortical thickness, gray-white matter contrast, local gyrification, sulcal depth, jacobian distance and curvature. To assess the effects of threshold and smoothing on detection sensitivity and specificity, we systematically varied these parameters with different thresholds and smoothing levels. To test the effectiveness of the technique to detect lesions of epileptogenic character, we compared the detected structural abnormalities to expert-tracings, intracranial EEG, pathology and surgical outcome in a homogeneous patient sample. With optimal parameters and by combining thickness and GWC, the surface-based detection method identified 92% of cortical lesions (sensitivity) with few false positives (96% specificity), successfully discriminating patients from controls 94% of the time. The detected structural abnormalities were related to the seizure onset zones, abnormal histology and positive outcome in all surgical patients. However, the method failed to adequately describe lesion extent in most cases. Automated surface-based MRI morphometry, if used with optimized parameters, may be a valuable additional clinical tool to improve the detection of subtle or previously occult malformations and therefore could improve identification of patients with intractable focal epilepsy who may benefit from surgery

    Rediscovery and status of \u3ci\u3eCylindera (s. str.) lunalonga \u3c/i\u3e(Schaupp, 1884) (Coleoptera: Carabidae: Cicindelinae) in the San Joaquin Valley of California with a comparison to a Sierra Nevada population

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    Surveys for adult Cylindera (s. str.) lunalonga (Schaupp) (Coleoptera: Carabidae: Cicindelinae) were conducted between 2001 and 2011 at over 80 sites throughout the species’ historic range in the San Joaquin Valley and Sierra Nevada Mountains of California. Previously considered extirpated from the Valley, these surveys resulted in finding adults at 18 sites, several with large populations (\u3e50 individuals). As suggested by historic records, our studies confirmed that the Valley populations of Cy. lunalonga occur in what were historically wetland sites, but are now lowland agricultural croplands. Adults were always associated with wet, muddy soil within and along the edges of irrigation ditches. A comparison of morphology, behavior, habitat, and conservation is made with the only known extant Sierra Nevada population. Note: Download button links to reduced-size version (2.4 Mb). Full-size version (122 Mb) is attached below as related file

    Functional, structural, and metabolic abnormalities of the hippocampal formation in Williams syndrome

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    Williams syndrome (WS), caused by microdeletion of some 21 genes on chromosome 7q11.23, is characterized by dysmorphic features, mental retardation or learning difficulties, elastin arteriopathy, and striking neurocognitive and social-behavioral abnormalities. Recent studies of murine knockouts of key genes in the microdeleted region, LIM kinase 1 (LIMK1) and cytoplasmatic linker protein 2 (CYLN2), demonstrated significant functional and metabolic abnormalities, but grossly normal structure, in the hippocampal formation (HF). Furthermore, deficits in spatial navigation and long-term memory, major cognitive domains dependent on hippocampal function, have been described in WS. We used multimodal neuroimaging to characterize hippocampal structure, function, and metabolic integrity in 12 participants with WS and 12 age-, sex-, and IQ-matched healthy controls. PET and functional MRI studies showed profound reduction in resting blood flow and absent differential response to visual stimuli in the anterior HF in WS. Spectroscopic measures of N-acetyl aspartate, considered a marker of synaptic activity, were reduced. Hippocampal size was preserved, but subtle alterations in shape were present. These data demonstrate abnormalities in HF in WS in agreement with murine models, implicate LIMK1 and CYLN2 in human hippocampal function, and suggest that hippocampal dysfunction may contribute to neurocognitive abnormalities in WS
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